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Lewin's Essential GENES, Third Edition

Author(s): Jocelyn E. Krebs, PhD, Professor, University of Alaska, Anchorage
Elliott S. Goldstein, PhD, Associate Professor, Arizona State University
Stephen T. Kilpatrick, PhD, Associate Professor, University of Pittsburgh at Johnstown
  • ISBN-13: 9781449644796
  • Product With Access Code    850 pages      © 2013
Price: $244.95 US List
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Extensively reorganized and revised with the latest data from this rapidly changing field, Lewin's Essential GENES, Third Edition, provides students with a comprehensive overview of molecular biology and molecular genetics. The authors took care to carefully modify the chapter order in an effort to provide a more clear and student-friendly presentation of course material.  Chapter material has been updated throughout, including a completely revised chapter on regulatory RNA, to keep pace with this advancing field.  The Third Edition's exceptional pedagogy enhances student learning and helps readers understand and retain key material like never before. Concept and Reasoning Checks at the end of each chapter section, End-of-Chapter Questions and Further Readings sections, as well as several categories of special topics boxes, expand and reinforce important concepts.

Features & Benefits

  • Reorganized chapter presentation provides a clear, student-friendly introduction to course material.
  • Completely revised chapter on Regulatory RNA provides new information in this rapidly advancing field.
  • The four replication chapters have been completely reorganized and include new sections describing eukaryote cell cycle control of replication.
  • Special Topics Boxes provide a balanced approach and serve to promote greater understanding of key material. These boxes fall into four-categories:
               -Essential Ideas boxes reinforce and clearly explain concepts critical to the chapter topics.
               -Medical Applications boxes provide clear links between basic molecular principles and human health
               -Historical Perspectives boxes supply the background information or experimental paths that led to our current knowledge
               -Methods and Techniques boxes describe how powerful methods in molecular biology are performed
  • Concept and Reasoning Checks consist of one or two questions at the end of each chapter section that ask students to pause and assess their understanding of the material they have just read. These questions require critical thinking or integration of section topics.
  • Key Concepts comprise bulleted lists of important points that follow each chapter section.
  • Further Readings at the end of every chapter direct students to current review articles and seminal research papers, providing further sources of information to reinforce and elaborate on chapter material.

Applicable Courses

Appropriate for the undergraduate course in molecular biology and molecular genetics at the college and university level.

Part  I  Genes and Chromosomes
  Chapter  1  Genes Are DNA
  Chapter  2  Genes Code for Proteins
  Chapter  3  Methods in Molecular Biology and Genetic Engineering
  Chapter  4  The Interrupted Gene
  Chapter  5  The Content of the Genome
  Chapter  6  Genome Sequences and Gene Number
  Chapter  7  Clusters and Repeats
  Chapter  8  Genome Evolution
  Chapter  9  Chromosomes
  Chapter  10  Chromatin
Part  II  DNA Replication and Recombination
  Chapter  11  Replication is Connected to the Cell Cycle
  Chapter  12  The Replicon: Initiation of Replication
  Chapter  13  DNA Replication
  Chapter  14  Extrachromosomal Replication
  Chapter  15  Homologous and Site-Specific Recombination
  Chapter  16  Repair Systems
  Chapter  17  Transposons, Retroviruses and Retrotransposons
  Chapter  18  Immune Diversity
Part  III  Gene Expression
  Chapter  19  Prokaryotic Transcription
  Chapter  20  Eukaryotic Transcription
  Chapter  21  RNA Splicing and Processing
  Chapter  22  mRNA Stability and Localization
  Chapter  23  Catalytic RNA
  Chapter  24  Translation
  Chapter  25  Using the Genetic Code
Part  IV  Gene Regulation
  Chapter  26  The Operon
  Chapter  27  Phage Strategies
  Chapter  28  Eukaryotic Transcription Regulation
  Chapter  29  Epigenetic Effects are Inherited
  Chapter  30  Regulatory RNA

Jocelyn E. Krebs, PhD-Professor, University of Alaska, Anchorage

Jocelyn E. Krebs received a B.A. in Biology from Bard College, Annandale-on-Hudson, New York, and a Ph.D. in Molecular and Cell Biology from the University of California, Berkeley. For her Ph.D. thesis, she studied the roles of DNA topology and insulator elements in transcriptional regulation. She performed her postdoctoral training as an American Cancer Society Fellow at the University of Massachusetts Medical School in the laboratory of Dr. Craig Peterson, where she focused on the roles of histone acetylation and chromatin remodeling in transcription. In 2000, Dr. Krebs joined the faculty in the Department of Biological Sciences at the University of Alaska, Anchorage, where she is now a Full Professor. Her most recent research focus has been on the role of the Williams syndrome transcription factor (one of the genes lost in the human neurodevelopmental syndrome Williams syndrome) in early embryonic development in the frog Xenopus. She teaches courses in introductory biology, genetics, and molecular biology for undergraduates, graduate students, and first-year medical students. She also teaches courses on the molecular biology of cancer and epigenetics. Although working in Anchorage, she lives in Portland, Oregon, with her wife and two sons, a dog, and three cats. Her nonwork passions include hiking, gardening, and fused glass work.


Additional Titles by this Author

Elliott S. Goldstein, PhD-Associate Professor, Arizona State University

Elliott S. Goldstein earned his B.S. in Biology from the University of Hartford in Connecticut and his Ph.D. in Genetics from the University of Minnesota, Department of Genetics and Cell Biology. Following this, he was awarded an NIH Postdoctoral Fellowship to work with Dr. Sheldon Penman at the Massachusetts Institute of Technology. After leaving Boston, he joined the faculty at Arizona State University in Tempe, Arizona, where he is an Associate Professor, Emeritus, in the Cellular, Molecular, and Biosciences program in the School of Life Sciences and in the Honors Disciplinary Program. His research interests are in the area of molecular and developmental genetics of early embryogenesis in Drosophila melanogaster. In recent years, he has focused on the Drosophila counterparts of the human protooncogenes jun and fos. His primary teaching responsibilities are in the undergraduate general genetics course as well as the graduate-level molecular genetics course. Dr. Goldstein lives in Tempe with his wife, his high school sweetheart. They have three children and two grandchildren. He is a bookworm who loves reading as well as underwater photography. His pictures can be found at

Stephen T. Kilpatrick, PhD-Associate Professor, University of Pittsburgh at Johnstown

Stephen T. Kilpatrick received a B.S. in Biology from Eastern College (now Eastern University) in St. Davids, Pennsylvania, and a Ph.D. from the Program in Ecology and Evolutionary Biology at Brown University. His thesis research was an investigation of the population genetics of interactions between the mitochondrial and nuclear genomes of Drosophila melanogaster. Since 1995, Dr. Kilpatrick has taught at the University of Pittsburgh at Johnstown in Johnstown, Pennsylvania, where he is currently chair of the Department of Biology. His regular teaching duties include undergraduate courses in introductory biology for biology majors and advanced undergraduate courses in genetics (for both majors and nursing students), evolution, and molecular genetics. He has also supervised a number of undergraduate research projects in evolutionary genetics. Dr. Kilpatrick’s major professional focus has been in biology education. He has participated in the development and authoring of ancillary materials for several introductory biology, genetics, and molecular genetics texts and online educational review sites as well as writing articles for educational reference publications. For his classes at Pitt-Johnstown, Dr. Kilpatrick has developed many active learning exercises in introductory biology, genetics, and evolution. Dr. Kilpatrick resides in Johnstown with his wife and four cats. Outside of scientific interests, he enjoys music, literature, and theater.

  • Chapter 1
    Preview Lewin`s Essential GENES Chapter 1
  • Chapter 4
    Preview Lewin`s Essential GENES Chapter 4

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ISBN-13: 9781449644796

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