Physicians’ Cancer Chemotherapy Drug Manual 2010

Edward Chu, MD-Professor of Medicine, Chief, Division of Hematology-Oncology, Deputy Director, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania

Dr. Edward Chu is a Professor of Medicine, Chief of the Division of Hematology-Oncology, and Deputy Director at the University of Pittsburgh Cancer Institute. He received his MD degree from Brown University, where he also completed his residency training in Internal Medicine Residency. He then went to the National Cancer Institute in Bethesda, MD for fellowship training in Medical Oncology. Following completion of his fellowship, he remained at the NCI as a Senior Clinical Investigator. In 1996, he was recruited as a Professor of Medicine and Pharmacology at the Yale University School of Medicine where he assumed the positions of Director of the VACT Cancer Center, Associate Director of the Yale Cancer Center, and co-Director of the Developmental Therapeutics Program at the Yale Cancer Center.

Dr. Chu is well-known for his basic research that has investigated the determinants of resistance to the fluoropyrimidine class of anticancer agents. In particular, his group has made seminal observations on the regulation of expression of thymidylate synthase, a critical target in cancer chemotherapy, with specific focus on elucidating novel translational regulatory mechanisms. In addition, his group is actively involved in developing novel compounds and strategies for the treatment of colorectal cancer as well as other human malignancies. He has worked closely with a number of drug companies to develop novel agents, and these companies include Roche, Bristol-MyersSquibb, Astra Zeneca, Eli Lilly, Pharmacia, GlaxoSmithKline, Imclone, Vion, and Tularik.  He serves on the scientific advisory boards of Advrx Pharmaceuticals, Celator, Etex, Phytoceutica, and Eximias, all of which are drug development companies.

He is the author of the Physicians’ Cancer Chemotherapy Drug Manual, which is now in its sixth edition, and this drug manual includes a comprehensive review of all of the main drugs and drug regimens currently used in clinical practice for oncology. He is the founding Editor-in-Chief of the clinical journal Clinical Colorectal Cancer and is the Chairman of the International Colorectal Congress, which is an annual international meeting focusing on management and treatment of colorectal cancer.