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Understanding Toxicology
A Biological Approach

Author(s): Steven Mercurio, PhD, Professor of Biology, Minnesota State University, Mankato, Minnesota
  • ISBN-13: 9780763771164
  • Paperback    952 pages      © 2017
Price: $94.95 US List
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Understanding Toxicology is a comprehensive study of toxicants and their impact on all levels of biology--from cell, to complex organism, to ecosystem. Unlike other texts of its kind, this text is uniquely structured by biological system, making it easy for readers to understand the impact of toxins on each system.  Common mechanisms are explored in the cellular and complex organ system chapters to approach a systems biology perspective that is more applicable to modern computational toxicology risk assessment.

Understanding Toxicology begins with three research questions that challenge the reader to discover what information is needed to solve controversies at the level of the cell, the complex organism, and the ecosystem. The book continues with a cellular, complex organism, and ecosystem analysis of toxicology principles including risk assessment. The cellular section follows common mechanisms from the outside to the inside of cells and individual organelles. A forensic approach analyzes complex organisms from outside to inside. The ecosystem section starts with a dispersion approach to determine environmental concentration and addresses toxicants in divisions similar to how the EPA determines impacts.

Key Features

  • Uses lively, engaging examples making the text fun and easy to read and understand
  • Allows the reader to approach the subject from a research perspective as well as a public policy perspective
  • Covers biological toxicants including venoms, poisons, as well as microbial and fungal toxins, and plant toxins
  • Thoroughly covers all organisms including fish, plants, and microbes
  • Includes outlines and review questions in each chapter
  Part  I  Introduction
    Chapter  1  Biological Research in Toxicology
    Chapter  2  Development of the Field of Toxicology
    Chapter  3  Toxicology Terms and How They Relate to Organisms
    Chapter  4  Hazard, Exposure, and Risk Modeling
  Part  II  Toxic of Reactions of Cells
    Chapter  5  Absorption and Transport of Toxicants through Membranes - Toxic Damage to Membranes
    Chapter  6  Receptor-Mediated Toxicities on the Outside of Cells
    Chapter  7  Detoxication and Activation by Cells - Metabolism of the Original Toxicant
    Chapter  8  Damage to Cytosolic and Endoplasmic Reticulum Activities
    Chapter  9  Damage to Mitochondrial and Chloroplast Activities
    Chapter  10  Damage to Nuclear Structures/DNA - Mutagenesis and Carcinogenesis
    Chapter  11  Selective Genetic Sensitivity of Cells to Toxicants
    Chapter  12  Nutritional Toxicity and Sensitivity
  Part  III  Toxic Reactions of Tissues/Organs
    Chapter  13  Routes of Administration and Which Organs are most likely Impacted Based on Route and Toxicokinetic Models
    Chapter  14  Forensic Toxicity Testing
    Chapter  15  The Skin and Eye: Most Likely Exposure Routes and Toxicities Due to Contact Exposure and Dose Toxicities
    Chapter  16  The G.I. System Toxicity and Oral Exposure (GI tract, pancreas, liver)
    Chapter  17  The Lung and Gill Exposures Representing Toxic Concentrations - Model for Environmental Toxicology
    Chapter  18  The Cardiovascular System as Conduit for a Dose Becoming a Dosage: Exposure and Toxicities
    Chapter  19  Bone Marrow and Immune Organ Toxicity via Lymphatic and Blood Transport
    Chapter  20  The Nervous System and Exposure to Lipophilic Toxicants or Transported Neurotoxic Agents
    Chapter  21  Toxicity to Neuroendocrine Organs and Endocrine Disruption
    Chapter  22  Toxicity to Reproductive Organs and Developmental Toxicity
    Chapter  23  Excretion of Hydrophilic Toxicants and Metabolites and Kidney Toxicity
  Part  IV  Toxic Reactions of Ecosystems
    Chapter  24  Dispersion Modeling in Air, Water and Soil. Likely Route of Exposure and Most Sensitive Organism Based on Dispersion and Concentration
    Chapter  25  Agricultural Chemicals (pesticides and fertilizers) Exposure and Impacts
    Chapter  26  Industrial Chemicals that Biodegrade: Organic Chemical Exposures and Impacts
    Chapter  27  Industrial Chemicals that Change Lipophilicity but Don’t Biodegrade: Metal Impacts
    Chapter  28  Industrial Chemicals that Cause Atmospheric Changes and Direct versus Indirect Toxicity: Gases, Vapors, Aerosols, and Radiation
    Chapter  29  Toxicity of Pharmaceuticals and Personal Care Products (PPCPs) into Water
  Part  V  Biological Toxicants
    Chapter  30  Venoms and Injection Toxicity versus Poisonous Animals or Cells and Ingestion or Contact Toxicity
    Chapter  31  Poisonous Plants or Plant Cells and Ingestion or Contact Toxicity

Steven Mercurio, PhD-Professor of Biology, Minnesota State University, Mankato, Minnesota

The following instructor resources are available to qualified instructors for download

ISBN-13: 9780763771164

Instructor Manual
Slides in PowerPoint Format
Test Bank

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