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Molecular Oncology of Prostate Cancer

Author(s): Jeffrey S. Ross, MD, Albany Medical College, Albany, New York
Christopher S. Foster, MD, PhD, The University of Liverpool, Liverpool, England
Details:
  • ISBN-13: 9780763747459
  • ISBN-10:0763747459
  • Hardcover    560 pages      © 2007
Price: Find Your Sales Rep International Sales $135.95 US List
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Overview

With the era of molecularly targeted therapy clearly established, prostate cancer is currently emerging as a forefront of discovery and implementation of personalized medicine strategies designed to individually select the best available treatment for each patient. This is the first book of its kind to focus on the molecular aspects of prostate cancer and how genetics, genomics and proteomics interact in the predisposition, development, progression and response to therapy of the disease. While serving as a concise reference text on the basic science and molecular biology of prostate cancer, Molecular Oncology of Prostate Cancer was written specifically for practicing urologists, medical and radiation oncologists, allied health pathologists, radiologists, and nurse oncologists who participate in the care of prostate cancer patients.

Molecular Oncology of Prostate Cancer emphasizes the genes, proteins and biologic pathways that are being evaluated today and will be tested in the future to derive the molecular signature of each newly diagnosed prostate cancer. This single volume offers readers relevant, up-to-date information on how these molecular-based tests are being used to discover the predisposition for developing the disease, how to detect it at the earliest stage possible, how to classify it based on its genetic fingerprint, and how to predict its therapy-specific outcome.

ShowKey Features

Provides a simplified, comprehensive overview of the complex molecular basis of prostate cancer

Emphasizes integrated molecular diagnostics

Offers a detailed focus on pathways of current interest, including specialized chapters on the EGFR pathway, the HER-2/neu pathway, and the androgen receptor pathways

Includes sections on pharmacogenomics and molecular classification

Contains chapters on functional imaging and the impact of molecularly targeted therapies on the U.S. FDA drug approval process

Designed specifically for practicing urologists, medical and radiation oncologists, as well as allied health pathologists, radiologists, and nurse oncologists

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ShowTable of Contents

Foreword

Chapter 1          Prostate Cancer and Molecular Medicine

Jeffrey S. Ross and Gennadi V. Glinsky

Chapter 2          Molecular Diagnostic Techniques in Prostate Cancer

Jeffrey S. Ross

Chapter 3          Molecular Epidemiology of Prostate Cancer

Jeffrey S. Ross

Chapter 4          Prostate Cancer Stem Cells

Jack A. Schalken and Christopher S. Foster

Chapter 5          Prostate Cancer Screening and Chemoprevention

Jacques Baillargeon, Ian Thompson, Javier Hernandez, and David P. Rose

Chapter 6          Molecular Methods, Including Reverse Transcriptase Polymerase Chain Reaction and Proteomics, for Prostate Cancer Screening and Detection of Recurrence and Micrometastasis

Douglas P. Malinowski

Chapter 7          Genomic Classification of Prostate Carcinoma

   William L. Gerald

Chapter 8          Pathology of Premalignant Lesions and Adenocarcinoma of Prostate

Minxin Che and Wael A Sakr

Chapter 9          Overview of Prognostic and Predictive Factors in Prostate Cancer

Jeffrey S. Ross, Timothy A. Jennings, Tipu Nazeer, Christine E. Sheehan, Hugh A.G. Fisher, Ronald A. Kauffman, and Bhaskar V.S. Kallakury

Chapter 10        Cytogenetics and Molecular Genetics of Prostate Cancer

Arthur R. Brothman, Teresa M. Maxwell, Joseph Pettus, and Stanford Putman

Chapter 11        DNA Ploidy and S Phase Analysis in Prostate Cancer

Jeffrey S. Ross, Merrill S. Ross, Metin Punar, Ann B. Boguniewicz, Tipu Nazeer, and Timothy Jennings

Chapter 12        Cell Proliferation Markers and Cell Cycle Regulators in Prostate Cancer

Jeffrey S. Ross, Scott E. Eggener, and Carlos Cordon-Cardo

Chapter 13        Targeted Therapies for Cancer: Integrating Diagnostics and Therapeutics

Jeffrey S. Ross

Chapter 14        The Androgen Receptor and Hormone-Based Therapies

Kristin A. Raclaw and Donald J. Tindall

Chapter 15        HER-2 and anti–HER-2 Targeted Therapies

Anjali Jain, Ronald L. Shazer, Isett Laux, Jeffrey S. Ross, and David B. Agus

Chapter 16        Epidermal Growth Factor Receptor and Other Growth Factors and Receptors

Begoña Mellado, Joan Carles, Jeffrey S. Ross, and Joan Albanell

Chapter 17        Proteases: Targets of Tumor Invasion and Metastasis

Christopher S. Foster and Christine Gosden

Chapter 18        Angiogenesis and Angiogenesis Inhibitors: Applications in Adenocarcinoma of the Prostate

Edwin M. Posadas and William L. Dahut

Chapter 19        Cell Adhesion Molecules in Prostate Cancer

Kenneth A. Iczkowski and Christopher S. Foster

Chapter 20        Cell Survival, Apoptosis, and Proapoptotic Therapies

Helgi van de Velde, Jeffrey S. Ross, and Michel Janicot

Chapter 21        Oncogenes

Joanne Edwards and John M. S. Bartlett

Chapter 22        p53 and Tumor Suppressor Genes in Prostate Cancer

Jeffrey S. Ross, Andre M. Oliveira, Jonathan A. Fletcher, Scott E. Eggener, and Carlos Cordon-Cardo

Chapter 23        Ubiquitin Pathway and Proteasome Inhibitors

Helgi van de Velde and Jeffrey S. Ross

Chapter 24      Significance of DNA Methylation in Prostate Cancer Initiation and Progression

Christopher S. Foster and Samantha J. Ireland

Chapter 25        Bioinformatics, Computational Biology, and Morphometrics

Olivier Saidi and David A. Verbel

Chapter 26        Prostate-Specific Membrane Antigen and Other Cell Surface Protein Targets for Antibody-Based Therapeutics and Immunotherapy in Prostate Cancer

Jeffrey S. Ross, Karen E. Gray, Iain Webb, Gary S. Gray, Mark Rolfe, David P. Schenkein, David M. Nanus, Mathew I. Milowski, and Neil H. Bander

Chapter 27        Gene Therapy and Immunotherapy for Prostate Cancer

Laura K. Aguilar, Douglas J. Jolly, and Estuardo Aguilar-Cordova

Chapter 28        Pharmacogenomics and Pharmacogenetics in Prostate Cancer

Jeffrey S. Ross, W. Fraser Symmans, Lajos Pusztai, and Gabriel N. Hortobagyi

Chapter 29        Functional and Molecular Imaging of Prostate Cancer

Neeta Pandit-Taskar and Chaitanya R. Divgi

Chapter 30        Evaluation and Assessment of Molecular Markers and Their Translation Into Clinical Practice

Michael W. Kattan

Chapter 31        Regulatory Aspects and Implications of Molecular Testing in the United States

Robert G. Pietrusko

Index

 


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ShowAbout the Author(s)

Jeffrey S. Ross, MD-Albany Medical College, Albany, New York

Jeffrey S. Ross, MD, is a graduate of Oberlin College, Oberlin, Ohio and The State University of New York at Buffalo School of Medicine in Buffalo, N.Y. He served as an intern resident and fellow in Anatomic and Clinical Pathology at the Massachusetts General Hospital in Boston, Mass. and was certified by the American Board of Pathology in Anatomic and Clinical Pathology in 1974. Following his training, Dr. Ross served as Chief of Pathology at the Moncrief United States Army Hospital in Fort Jackson, South Carolina. From 1977 until 1989, he was a member of the faculty of the University of Massachusetts Medical School reaching the rank of Professor and Assistant Dean while continuing as research Assistant Professor at Harvard Medical School and the Massachusetts General Hospital. In 1989, he became the Cyrus Strong Merrill Professor and Chairman of the Department of Pathology and Laboratory Medicine at the Albany Medical College and Pathologist-in-Chief at the Albany Medical Center Hospital in Albany, N.Y. The Pathology and Laboratory Medicine Department at Albany Medical Center is a large academic pathology and clinical laboratory practice and provides services to a network of community hospitals, multi-specialty physician groups, governmental agencies, extended care facilities and for-profit regional and national laboratory companies throughout upstate New York and western New England. This program was privatized in 2002 as Affiliated Pathology Services, Inc. with Dr. Ross serving as President and Chief Executive Officer.

Dr. Ross has received numerous academic awards, three patents in molecular diagnostics and is the author of more than 470 peer-reviewed scientific articles, research abstracts, three textbooks and numerous book chapters in the fields of pathology, molecular diagnostics, oncology and translational cancer research. At Albany Medical College, Dr. Ross directs a federally funded research laboratory in molecular pathology. Since 2000, Dr. Ross has been a member of the NIH Clinical Oncology Study Section. He serves on the editorial boards and reviewer lists of numerous scientific journals and is Associate Editor for Basic Science of the American Journal of Clinical Pathology. He has served in multiple leadership positions for the American Society of Clinical Pathologists, the College of American Pathologists, the International Academy of Pathology and the Association of Pathology Chairs. Dr. Ross is a member of the Scientific Advisory Boards of the Welch-Allyn Corporation and Tripath Oncology, Inc. In December 1999, on semi-sabbatical leave, Dr. Ross was named Scientific Fellow and Head of Molecular Pathology at Millennium Pharmaceuticals, Inc. of Cambridge, Mass. Currently, Dr. Ross continues to serve as Senior Scientific Fellow for Oncology Molecular Medicine at Millennium and Chairman of the Department of Pathology and Laboratory Medicine at the Albany Medical College and the Albany Medical Center Hospital.

Additional Titles by this Author

Christopher S. Foster, MD, PhD-The University of Liverpool, Liverpool, England

Christopher S. Foster, MD, PhD, is Professor of Cellular Pathology and Molecular Genetics in the School of Laboratory Sciences at The University of Liverpool, Royal Liverpool University Hospital in Liverpool, UK.

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