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Apoptosis, Genomic Integrity and Cancer

Author(s): Julien L. Van Lancker, MD, University of California, Los Angeles, California
Details:
  • ISBN-13: 9780763745417
  • ISBN-10:0763745413
  • Hardcover    422 pages      © 2006
Price: International Sales $223.95 US List
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Overview

Harmonious survival of the entire organism depends on the rigorous preservation of the controls that regulate the balance between the cell’s replication and apoptosis. This balance depends largely, although not exclusively, on the integrity of the genome. Cancer is a flagrant illustration of the danger of imbalance between cell proliferation and cell death.  As cells replicate unfettered by normal controls, they invade the surrounding healthy population of cells, and they colonize distant organs. Van Lancker’s book introduces readers to the molecules involved in apoptosis and genomic integrity and considers the gain or loss of the functions that lead to cancer. This excellent educational resource is designed for scientists and academics in the medical sciences, graduate and undergraduate education in cell biology, biochemistry, physiology, pharmacology, public health, toxicology, experimental pathology, and radiation biology. 

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Introduction to Apoptosis

Foreword by Wayne Grody, MD.

Part 1 Introduction to Apoptosis
1.        Morphology and Occurence of Apoptosis
2.       Recognition and Disposal of the Apoptotic Bodies
3.       Agents that Trigger Apoptosis
4.       Genes and Gene Products in Apoptosis of C. elegans
5.       The Bc1-2 Family
6.       Interleukin 1-B Converting Enzyme (ICE) and Caspases
7.       The Cytochrome c-Dependent Pathway to Apoptosis
8.       Inhibitor of Apoptosis Proteins (IAPs)

Part 2 Integrity of the Genome
9.      The p53 Gene
10.      Integrity of the Genome and Programmed Cell Death
11.     Enzymes Potentially Involved in P53 Activation
12.     P53 and the Cell Cycle
13.     Cell Cycle Checkpoints
14.     Cell Cycle Arrests
15.     P53 Transactivation of GADD45 and MDM2
16.      The P53 Family and Apoptosis

Part 3 The Life and Death of the Cancer Cell
17.     Tumor Transforming Growth Factors and Cancer
18.     Protein Tyrosine Kinase Receptors and Cancer
19.     The Oncogenic GTPases
20.     Non-Receptor Protein Kinases and Cancer
21.     The PiK3/AKT Pathway Cancer and Apoptosis
22.     Transcription Factors and Cancer
23.     Cancer and Genomic Instability
24.     Cancer and Genomic Instability: Mismatch Repair and Cancer
25.     The Role of Franconi Anemia, Breast Cancer and Bloom Syndrome Genes in Oncogensis
26.      Cancer and Apoptosis

 


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ShowAbout the Author(s)

Julien L. Van Lancker, MD-University of California, Los Angeles, California

Julien L. Van Lancker, MD, is currently a Professor Emeritus of Pathology and Laboratory Medicine as well as Professor Emeritus in Radiation Oncology at the University of California School of Medicine, Los Angeles. He has also been a doctor in Medicine, Diplomate in Pathology, and Diplomate in Radiological Oncology at the University of Louvain (Belgium); Professor of Pathology and Radiology at the University of Wisconsin, Madison; Professor of Medical Sciences and Chair of Pathology at Brown University, Rhode Island; and Chairman of the Department of Pathology and Laboratory Medicine at the University of California, Los Angeles. 

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This book was designed for scientists and academics in the medical sciences, graduate and undergraduate education in cell biology, biochemistry, physiology, pharmacology, public health, toxicology, experimental pathology, and radiation biology.

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