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Genomic and Molecular Neuro-Oncology

Author(s): Wei Zhang, PhD, MD, Anderson Cancer Center, Texas
Gregory N. Fuller, MD, PhD, Anderson Cancer Center, Texas
  • ISBN-13: 9780763722616
  • ISBN-10:0763722618
  • Hardcover    344 pages      © 2004
Price: $510.95 US List
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In recent years, cutting-edge genomic and molecular techniques have profoundly influenced the direction of brain tumor research and modern clinical practice. Genomic and Molecular Neuro-Oncology, edited by Wei Zhang and Gregory N. Fuller, is an up-to-date reference that documents these important advances and describes their medical and therapeutic implications. Written for a broad range of researchers and clinicians including oncologists, neurologists, pathologists, neuroscientists, residents, postdoctoral fellows, and others in related fields, this volume contains 18 contributions organized in five sections: Genomic and Genetic Alterations in Gliomas, Molecular Alterations in Gliomas, Genomics and Informatics, Animal Models, and Molecular Therapeutics. Each chapter provides a review of a specific subfield of contemporary molecular neuro-oncology, including recently implemented diagnostic and research applications.

This book focuses on the latest genomics, molecular, and informatic approaches to neuro-oncology. The broad range of applications illustrated include the facilitation of clinical diagnosis through molecular and genomics techniques, the identification, confirmation and validation of new tumor markers and novel therapeutic targets, gene discovery and subsequent pathway and biology elucidation, and the emerging molecular approach to brain tumor classification. There is a naturally symbiotic relationship between advances in basic knowledge generated through bench research and the clinical translation and application of that knowledge that forms the foundation for each of the chapters in Genomic and Molecular Neuro-Oncology.

Features & Benefits

The first book that highlights the latest genomic, molecular approaches, and informatics applied to human brain tumor classification and target identification.

Contains a comprehensive review on genomic instabilities, mRNA splicing, key signal transduction pathways, and tumor suppressor genes important for neuro-oncology.

Includes a thorough review of animal models, especially recently developed glial-specific transgenic models, used in contemporary neuro-oncology research.

Thoroughly documents the translation of modern neuro-oncology research to clinical therapeutics.

Applicable Courses

The target audience for Genomic and Molecular Neuro-Oncology is broad and includes clinicians, neuroscientists, graduate students, medical residents, and postdoctoral fellows working in the field of neuro-oncology and related disciplines. Because of the focus on very timely, state-of-the-art genomics approaches, the book will also be of interest to genomics researchers, molecular biologists, bioinformaticians and statisticians in all fields of biological and biomedical research. This book is appropriate for all institutions that have cancer biology-related educational programs at college and graduate school levels and can be used as the core or main text for Neuro-oncology courses and as a supplementary book for all other cancer biology-related courses.

Primary course examples: 

  • Neuro-oncology
  • Neurosurgery
  • Neurology
  • Neuropathology

Secondary course examples:

  • Cancer Biology
  • Genomic Biology
  • Cell Biology


Part I: Genomic and Genetic Alterations in Gliomas
Ch. 1: Methylation and Genomic Damage in Gliomas; Oliver Bögler and Webster K. Cavenee
Ch. 2: Molecular and Clinical Aspects of 1p-19q Loss in Oligodenroglioma; J. Matthew
McDonald, Howard Colman, Arie Perry, Ken Aldape

Ch. 3: Functional Inactivation of p53 in Gliomas; Woonyoung Choi, Federick Lang, Wei Zhang
Ch. 4: PTEN: A Tumor Suppressor Gene Frequently Mutated in Glioblastomas; Michael Davies
Ch. 5: Molecular Genetics of the SWI/SNF Family Gene INI1 in Atypical Teratoid/Rhabdoid Tumors; Jaclyn A. Biegel

Part II: Molecular Alterations in Gliomas
Ch. 6: Molecular Markers in Diagnosis and Classification; Janet M. Bruner
Ch. 7: Molecular and Biological Determinants of Invasiveness and Angiogenesis in Central Nervous System Tumors; Sunyun Huang, Sujit Prabhu, and Raymond Sawaya,
Ch. 8: Insulin-like Growth Factors and Insulin-like Growth Factor Binding Proteins in CNS Tumors; Hua Wang, Gregory N. Fuller, and Wei Zhang

Part III: Genomics and Informatics
Ch. 9: Glioma Transcriptomes: Classifiers and Classification; Wei Zhang, Ellen Taylor, Chang Hun Rhee, and Gregory N. Fuller
Ch. 10: Tissue Microarrays: Applications In Neuro-Oncology Research; Teresa Ribalta, Huamin Wang, and Gregory N. Fuller
Ch. 11: Abnormal Regulation of RNA Splicing in Gliomas; Gilbert J. Cote, Ivone G. Bruno, and Wei Jin
Ch. 12: Chromsomal Imbalances in Oligodendroglial Tumors as Detected by Comparative Genomic Hybridization; Judith W.M. Jeuken, Sandra H.E. Boots-Sprenger, and Pieter Wesseling
Ch. 13: Statistical Considerations in the Design and Analysis of Microarray Experiments; Kenneth R. Hess
Ch. 14: Transcriptome-Based Glioma Classification Using Informative Gene Set; Ioan Tabus, Christian Mircean, Ilya Shmulevich, Wei Zhang, and Jaakko Astola

Part IV: Animal Models
Ch. 15: Mouse Models for Infiltrative Gliomas; Isha T. Seales, Ken Aldape, and William A.Weiss
Ch. 16: Dissecting Gliomagenesis Using Glial-Specific Trangenic Mouse Models; Martin Begemann, Lene Uhrbom, Vinagolu K. Rajasekhar, Gregory N. Fuller, and Eric C. Holland

Part V: Molecular Therapeutics
Ch. 17: Gene Therapy for Malignant Gliomas: Targeting the Cancer Genomes; Robert Stolarek, Juan Fueyo, Candelaria Gomez-Manzano, Hong Jiang, and W.K. Alfred Yung
Ch. 18: Therapeutic Targeting of the Molecular Pathways That Induce Brain Tumor Development; Erwin G. Van Meir, Chunhai Hao, Dawn E. Post, Linda M. Liau, and Daniel J. Brat

Wei Zhang, PhD, MD-Anderson Cancer Center, Texas

Dr. Wei Zhang received a Ph.D. degree from The University of Texas Graduate School of Biomedical Sciences. He joined the faculty of M. D. Anderson Cancer Center in 1994 where he is currently an Associate Professor and the Director of the Cancer Genomics Core Laboratory. Dr. Zhang’s research programs include cancer genomics and informatics, tumor suppressor genes, and signal transduction studies. Dr. Zhang has published over 90 peer-reviewed research papers, 10 book chapters and a book on Statistical and Computational Approaches to Genomics. Dr. Zhang is an Associate Editor for American Association of Cancer Research journal Clinical Cancer Research, and serves on editorial board of journals Cancer Biology and Therapy, Technology in Cancer Research and Treatment, and Molecular Cancer.

Gregory N. Fuller, MD, PhD-Anderson Cancer Center, Texas

Dr. Gregory Fuller received a Ph.D. degree from The University of Texas Graduate School of Biomedical Sciences and M.D. degree from Baylor College of Medicine. Following residency and fellowship training at Duke University, he joined the faculty of M. D. Anderson Cancer Center in 1992 where he is currently Professor and Chief of the Sections of Neuropathology and Immunocytochemistry, and Director of the Molecular Hybridization and Tissue Microarray Laboratories. Dr. Fuller’s research program is focused on molecular paradigms for brain tumor classification, for which he received the Lucian J. Rubinstein Award from the American Association of Neuropathologists in 2002. Dr. Fuller has published over 120 peer-reviewed research papers, 25 book chapters and two textbooks.

  • This book is important for its view of many of the recent developments in cancer biology as they are applied to gliomas. It focuses deeply needed light on the ways in which genomic and postgenomic approaches are beginning to reshape our understanding of the biology underlying glioma formation, progression, and response to treatment. Zhang and Fuller have assembled an outstanding group of contributors, and the chapters are...very well written…Among the many excellent chapters in this book, those on methylation and genomic damage (Chapter 1), abnormal regulation of RNA splicing (Chapter 11), and the RCAS/TVA mouse genetic model (Chapter16) are exceptionally well written and informative…In summary, this book fills an important niche in molecular neuro-oncology and provides a welcome new resource for glioma researchers, particularly for new researchers entering the field.”


    —From review by Paul S. Mischel, UCLA, in Neuro-Oncology
    (May 13, 2004)



    Genomic and Molecular Neuro-Oncology does a good job introducing some basic tenets of various oncogenic pathways, timely technology, and importantly, the clinical application of molecular targeting. The extensive list of references that follow each chapter make this book a springboard for a more in-depth analysis. As a text, it offers something for everybody, fulfilling the need of a graduate student interested in an introduction to cancer research, an experienced researcher interested in learning about a specific molecular pathway, or a neurosurgeon wanting an overview of molecular oncology. Having this book on the shelf provides valuable resource for those individuals looking to impede these deadly forms of cancer.”

    —From review by Akiva Mintz, Pennsylvania State University College of Medicine, Landes Bioscience (April 2004)

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