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Essential Genetics, Sixth Edition
A Genomics Perspective

Author(s): Daniel L. Hartl, PhD, Harvard University
  • ISBN-13: 9781449686888
  • Product With Access Code    574 pages      © 2014
Price: $187.95 US List
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Every new copy includes access to the student companion website

Updated throughout to reflect the latest discoveries in this fast-paced field, Essential Genetics: A Genomics Perspective, Sixth Edition, provides an accessible, student-friendly introduction to modern genetics.  Designed for the shorter, less comprehensive course, the Sixth Edition presents carefully chosen topics that provide a solid foundation to the basic understanding of gene mutation, expression, and regulation. It goes on to discuss the development and progression of genetics as a field of study within a societal and historical context.  The Sixth Edition includes new learning objectives within each chapter which helps students identify what they should know as a result of their studying and highlights the skills they should acquire through various practice problems.

What's new in the Sixth Edition?

  • Chapter 1 includes a new section on the origin of life
  • Chapter 2 includes a revised discussion of the complementation test and how it is used to determine whether two mutations have defects in the same gene
  • Chapter 3 incorporates new data showing that the folding of interphase chromatin into chromosome territories has the form of a fractal globule.  It also includes a new section on progenitor cells and embryonic stem cells
  • Chapter 4 includes a new section discussing how copy-number variation in human amylase evolved in response to increased dietary starch as well as the latest on hotspots of recombination
  • Chapter 5 is updated with the latest information on hazards of polycarbonate food containers.  It also includes a new section on the genetics of schizophrenia and autism spectrum disorder
  • Chapter 6 includes a revised section on restriction mapping and also discusses the newest massively parallel DNA sequencing technologies that can yield the equivalent of 200 human genomes' worth of DNA sequence in a single sequencing run
  • Chapter 7 has been updated with a shortened and streamlined discussion of recombination in bacteriophage
  • Chapter 8 includes new discoveries concerning the mechanisms of intrinsic transcriptional termination as well as rho-dependent termination
  • Chapter 9 is updated with a new section on stochastic effects on gene expression and an expanded discussion of the lactose operon. There is also a revised discussion of galactose gene regulation in yeast, as well as new sections on long noncoding RNAs
  • Chapter 10 includes new sections on ancient DNA sequences of the Neandertal and Denisovan genomes
  • Chapter 11 examines master control genes in development
  • Chapter 12 includes a new section on the repair of double-stranded breaks in DNA by nonhomologous end joining or template-directed gap repair
  • Chapter 13 has been extensively revised with the latest data on cancer.
  • Chapter 14 includes a new section on the detection of natural selection, as well as a new section on conservation genetics
  • Human Evolutionary Genetics integrated throughout the text.

Key Features of Essential Genetics, Sixth Edition:

  • New Learning Objectives within each chapter help students to:
    • Identify what they should know or be able to do as a result of their study
    • Focus on the knowledge they should have acquired from studying the chapter
    • Guide them to identify key concepts and use them at a variety of learning levels including comprehension, application, analysis, and synthesis
    • Highlight the skill they should acquire through practice of various problem types
  • Each chapter includes several different types and levels of problems, including: concept, synthesis, and discussion questions, problem solving questions, and application and analysis problems.
  • The companion Website, GeNETics on the Web, includes numerous study tools and learning resources such as animated flashcards, crosswords, and practice quizzes
  • An electronic Student Study Guide and Solutions Manual is available, containing chapter summaries, key terms, and extra study questions, as well as worked solutions for all Concepts in Action problems.
  • The Instructor's Media CD-ROM includes a PowerPoint Image Bank and PowerPoint Lecture Slides. An online Test Bank is also available for use in most course management systems.


Applicable Courses

Ideal for use in introductory genetics courses offered at the undergraduate level.

  Chapter 1  The Genetic Code of Genes and Genomes
  Chapter 2  Transmission Genetics: Heritage from Mendel
  Chapter 3  The Chromosomal Basis of Heredity
  Chapter 4  Gene Linkage and Genetic Mapping
  Chapter 5  Human Chromosomes and Chromosome Behavior
  Chapter 6  DNA Structure, Replication, and Manipulation
  Chapter 7  The Genetics of Bacteria and Their Viruses
  Chapter 8  The Molecular Genetics of Gene Expression
  Chapter 9  Molecular Mechanisms of Gene Regulation
  Chapter 10  Geonomics, Proteomics, and Genetic Engineering
  Chapter 11  The Genetic Control of Development
  Chapter 12  Molecular Mechanisms of Mutation and DNA Repair
  Chapter 13  Molecular Genetics of the Cell Cycle and Cancer
  Chapter 14  Molecular Evolution and Population Genetics
  Chapter 15  The Genetic Basics of Complex Inheritance

Daniel L. Hartl, PhD-Harvard University

Daniel L. Hartl is Higgins Professor of Biology in the Department of Organismic and Evolutionary Biology at Harvard University.  He has authored or coauthored more than 300 scientific articles and 20 books in genetics, genomics, molecular evolution, and population genetics.  He has served as president of the Genetics Society of America and the Society for Molecular Biology and Evolution. He has also served as Chairman of his department at Harvard. He is was elected to the National Academy of Sciences and the American Academy of Arts and Sciences. He received his PhD from the University of Wisconsin.  His research interests include evolutionary genomics, molecular evolution and population genetics.

Additional Titles by this Author

The following instructor resources are available to qualified instructors for download

ISBN-13: 9781449686888

Angel ready Test Bank
BlackBoard ready Test Bank
Desire to Learn ready Test Bank
Image Bank
Moodle ready Test Bank
Slides in PowerPoint Format
Test Bank

Student Study Guide and Solutions Manual (ExpressPDF)

ISBN-13: 9781449696269

The Student Study Guide and Solutions Manual (ExpressPDF) to accompany Essential Genetics, Sixth Edition includes additional problem sets as well as complete solutions that are not found on the companion website.

Please note, ExpressPDF products are not currently supported for use on mobile devices.


Essential Genetics, Sixth Edition with Navigate Essential Genetics

Bundle ISBN: 9781284043853
This bundle includes the print version of Essential Genetics, Sixth Edition with 365-day online access to Navigate Essential Genetics.