Introduction
Part 1 Background Information
Chapter 1.1 The Purpose of This Handbook
Chapter 1.2 Your Mission on the IRB
Chapter 1.3 A Brief History of the IRB System
Chapter 1.4 Principles of the Belmont Report
Chapter 1.5 Definition of Human Subject Research, Exempt & Expedited Review Categories
Part 2 The Full Committee IRB Meeting
Chapter 2.1 The Work Before An IRB Meeting
Chapter 2.2 Reviewing a New Research Proposal
Chapter 2.3 The Consent Process and Document
Chapter 2.4 Continuing Review of Research
Chapter 2.5 Protocol Revisions
Chapter 2.6 Data and Safety Monitoring and Adverse Event Reporting
Chapter 2.7 Primary Reviewer Presentations
Chapter 2.8 Deciding How to Vote
Part 3 Specific Topics
Chapter 3.1 Evaluating Study Design and Quality
Chapter 3.2 Researcher Conflict of Interest
Chapter 3.3 IRB Member Conflict of Interest
Chapter 3.4 Advertisements for Research
Chapter 3.5 Paying Research Subjects
Chapter 3.6 Denying Subjects Access to Research Results
Chapter 3.7 Deception of Research Subjects
Chapter 3.8 Qualitative Social Science Research
Chapter 3.9 Research Without Informed Consent or Documentation
Chapter 3.10 Exculpatory Language in the Consent Document
Chapter 3.11 When are Research Risks Reasonable in Relation to Anticipated Benefits?
Chapter 3.12 Research Involving Children
Chapter 3.13 Regulatory Issues of Research Involving Prisoners
Chapter 3.14 Placebo Controlled Trials
Chapter 3.15 Phase 1 Oncology Trials
Chapter 3.16 Health Insurance Portability and Accountability Act
Part 4 Resources for Additional Information
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